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In PIONEER 3, patients were randomised to oral semaglutide 3, 7 or 14 mg once daily or sitagliptin 100 mg once daily added to background metformin with or without a sulphonylurea [7]

For selected patients, yes

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For an individual who had lost a fifth of their weight while on the drugs, this would correspond to a sustained weight reduction of around 5%, the authors said

[7] Neither pattern fits a take X mcg at bedtime model

SGLT2 inhibitor use is associated with a reduction in both fat mass and lean body mass (measured using a range of techniques) similar to that caused by GLP-1 receptor agonists